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【PPT】使用湿法制粒开发低剂量固体口服制剂

  • 2026-11-01 06:29:26
【PPT】使用湿法制粒开发低剂量固体口服制剂
编者语：本章围绕湿法制粒技术开发低剂量固体口服制剂展开论述，系统介绍制粒机制、常规工艺考量、优劣势分析、低剂量制剂应用、工艺相关形态变化及研究结论。湿法制粒作为口服固体制剂经典且应用广泛的生产工艺，具备优异的工艺稳健性，可弱化原料药性质变异性，保障制剂性能稳定可预期。低剂量制剂生产存在显著技术难点，工艺选择与原料药性质高度相关，湿法制粒虽不适用于全部化合物，但仍是该领域研究与应用最成熟的工艺。其流程复杂的不足，可转化为多工序质量控制的优势，便于制剂研究者通过多环节调控，系统构建并保障最终制剂质量。本文选自：《FORMULATION AND ANALYTICAL DEVELOPMENT FOR LOW-DOSE ORAL DRUG PRODUCTS 》第5章《使用湿法制粒开发低剂量固体口服制剂》
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  14. SELECT * FROM `article` WHERE `id` < 470828 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.000588s ]
  15. SELECT * FROM `article` WHERE `id` < 470828 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.000624s ]
0.087433s