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【PPT】90页讲清阿尔茨海默病:机制、诊断到治疗

  • 2026-07-17 02:00:45
【PPT】90页讲清阿尔茨海默病:机制、诊断到治疗

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1901年11月25日，这在医学史上是重要的一天。在这一天上午，Auguste Deter，一位51岁的老妇人在丈夫的伴随下走到了法兰克福的一家精神医院，并接受了中年医生的诊治。于是就出现了如上的对话，阿尔兹海默发现此病人对时间与地点毫无概念，对生活中发生事件的细节部分也难以记住，她的情绪也不断的在焦虑、猜疑、退缩等中快速的变化，阿尔兹海默意识到这是一种新的疾病，并且给Auguste Deter拍了照片，他没有想到的是他所拍的这张照片当今几乎出现在每一本神经病学教科书中。Auguste Deter也成为了历史上第一个得到记载的老年痴呆症的病例。1906年，Auguste Deter死后，阿尔兹海默用Nissl的染色方法对她的脑切片进行染色，再通过显微镜仔细的观察，发现了Auguste脑切片有两个明显特征：淀粉样斑块与深颜色的神经原纤维缠结——现在被称为为神经纤维缠结。这项发现后来被Purusini、Kraepelin、 Fischer等人证实，1910年，Emil Kraepelin教授将这种新发现的严重的老年痴呆症命名为Alzheimer’s disease。

文字引用：阿尔茨海默病的前世今生-CZC的个人博客

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  1. CONNECT:[ UseTime:0.000431s ] mysql:host=127.0.0.1;port=3306;dbname=h_sjds;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000539s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000253s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000319s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000639s ]
  6. SELECT * FROM `set` [ RunTime:0.000222s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000581s ]
  8. SELECT * FROM `article` WHERE `id` = 541578 LIMIT 1 [ RunTime:0.024660s ]
  9. UPDATE `article` SET `lasttime` = 1784443359 WHERE `id` = 541578 [ RunTime:0.002605s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000272s ]
  11. SELECT * FROM `article` WHERE `id` < 541578 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000459s ]
  12. SELECT * FROM `article` WHERE `id` > 541578 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.009599s ]
  13. SELECT * FROM `article` WHERE `id` < 541578 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000668s ]
  14. SELECT * FROM `article` WHERE `id` < 541578 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.006937s ]
  15. SELECT * FROM `article` WHERE `id` < 541578 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.004778s ]
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