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PPT总结|辅助生殖促排监测过程中E2浓度值与卵泡发育的关系以及应用现状

辅助生殖促排过程中会看E2浓度来同步评估卵泡发育情况，最常用的标准认为每成熟卵泡对应200-300pg/ml E2浓度值；最近工作是碰到了相关内容，故将目前能检索到的内容进行展示，力求展示真实现状：

本篇将回答三个问题：

注：本篇内容受限于检索深度及广度的影响，不一定非常客观。

尽量检索了跟E2/卵泡数相关的文献，展示如下：

临床上判断时需要结合用药方案

除了本身标准定义不清、用药方案，个体差异等因素外，E2本身检测也存在局限性。

26年7月新发表的文献，对于卵泡直径与E2浓度不呈线性关系的原因并未阐述；

原文链接：

注：E2水平是参考指标但不是扳机的决定性指标

原文链接：

控制性卵巢刺激周期中扳机时机及方法选择（2025）

参考文献名称：（按照ppt展示顺序排序，实在不想管引用格式了，请见谅）

ppt第二页：

The LH surge and ovulationre-visited:a systematic review and meta-analysis and implications for true natural cycle frozen thawed embryo transfer（2022）
Analytical and clinical evaluation of the Immulite estradiol assay in serum from patients undergoing in vitro fertilization: estradiol increase in mature follicles. Clin Chem. 1997 Jul;.
Speroff L, Fritz MA. Endocrinologíaginecológicaclínica y esterilidad. Madrid: Wolters Kluwer / Lippincott Williams & Wilkins; 2007.

ppt第三页：

Analytical and clinical evaluation of the Immulite estradiol assay in serum from patients undergoing in vitro fertilization: estradiol increase in mature follicles. Clin Chem.
Clinical Validation of a Fully Automated 17-Estradiol andProgesterone Assay (VIDAS®) for Use in Monitoring AssistedReproduction Treatment
Orvieto R, Homburg R. The influence of estradiol/follicle and estradiol/oocyte ratios on the outcome of controlled ovarian stimulation for in vitro fertilization. Gynecol Endocrinol.
Mittal S. Serum estradiol as a predictor of success of in vitro fertilization. J ObstetGynaecol India.
Hu X. New Perspectives on Criteria for the Determination of HCG Trigger Timing in GnRH Antagonist Cycles. Medicine (Baltimore).
Relationship between a low ratio of serum estradiol to follicle number and fertility treatment outcomes: A retrospective cohort study of 516 cases
Yang, T., Does the weekend matter? evaluating the weekend effect on pregnancy outcomes in first-cycle fresh IVF/ICSI embryo transfers: a retrospective study.

ppt第五-九页：

Relationship between a low ratio of serum estradiol to follicle number and fertility treatment outcomes: A retrospective cohort study of 516 cases（2018）
Peavey M, Akbas N, Gibbons W, Zarutskie P, Devaraj S. Optimization of oestradiol assays to improve utility in an in vitro fertilization setting. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 2018;
Guo M, Wang Z. Harmonization and standardization for selection of high-trueness estradiol assay kits in serum and evaluation of estradiol levels relative to follicle diameters on trigger days. Front Med (Lausanne). 2026 Jul 13;
ESHRE guideline: ovarian stimulation for IVF/ICSI: an update in 2025, Human Reproduction, Volume 41, Issue 4, April 2026, Pages 498–514,
谢诗，伍琼芳.控制性卵巢刺激周期中扳机时机及方法选择［J］.中国实用妇科与产科杂志，2025,41(12)：1169-1173.

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